(1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: a novel class of potent MSK-1-inhibitors

Bioorg Med Chem Lett. 2005 Jul 15;15(14):3402-6. doi: 10.1016/j.bmcl.2005.05.021.

Abstract

A novel series of imidazo[4,5-c]pyridines bearing a 1,2,5-oxadiazol-3-ylamine functionality has been developed. These are potent inhibitors of mitogen and stress-activated protein kinase-1.

MeSH terms

  • Amines / chemical synthesis
  • Amines / classification
  • Amines / pharmacology*
  • Enzyme Inhibitors / chemical synthesis
  • Enzyme Inhibitors / classification
  • Enzyme Inhibitors / pharmacology*
  • Imidazoles / chemical synthesis
  • Imidazoles / classification
  • Imidazoles / pharmacology*
  • Molecular Structure
  • Oxadiazoles / chemical synthesis
  • Oxadiazoles / classification
  • Oxadiazoles / pharmacology*
  • Pyridines / chemical synthesis
  • Pyridines / classification
  • Pyridines / pharmacology*
  • Ribosomal Protein S6 Kinases, 90-kDa / antagonists & inhibitors*
  • Structure-Activity Relationship

Substances

  • Amines
  • Enzyme Inhibitors
  • Imidazoles
  • Oxadiazoles
  • Pyridines
  • Ribosomal Protein S6 Kinases, 90-kDa
  • mitogen and stress-activated protein kinase 1